Introduction
Pan-Can 40 mg Injection is an intravenous proton pump inhibitor (PPI) for rapid control of gastric acid secretion in hospitalized patients. It is formulated as lyophilized powder for reconstitution and is intended for IV use only.
Composition
Each vial contains:
| Ingredient | Quantity |
|---|---|
| Pantoprazole Sodium IP eq. to Pantoprazole | 40 mg |
| (Sterile lyophilized powder for IV use only) |
Supplied with: 1 vial + 10 ml Sodium Chloride 0.9% ampoule
Reconstitution: Add 10 ml NaCl 0.9% to vial; use immediately after reconstitution.
Benefits of Pan-Can Injection
- Rapid onset of acid suppression for acute upper GI bleeding and erosive esophagitis.
- IV delivery for patients unable to tolerate oral PPIs.
- Stress ulcer prophylaxis in critically ill patients.
- Stable lyophilized format for extended shelf life.
Mechanism of Action
Pantoprazole irreversibly inhibits the H+/K+ ATPase enzyme system at the secretory surface of gastric parietal cells, blocking the final step of acid production.
Recommended Dosage
- Adults: 40 mg IV once daily, administered over 15-30 minutes.
- For severe cases, an initial 80 mg IV bolus may be used followed by 40 mg IV once daily.
- Use in line with hospital protocol and physician direction.
Precautions
- Not to be used in patients with known hypersensitivity to pantoprazole or substituted benzimidazoles.
- Use with caution in patients with liver impairment.
- Monitor for signs of hypomagnesemia, especially with prolonged therapy.
- Reconstitute with sterile water for injection before administration; discard unused portion.
Conclusion
Pan-Can 40 mg IV provides reliable acid suppression in acute care settings where oral therapy is impractical. It supports effective management of gastroesophageal conditions under professional supervision.